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- Title
IL-2 therapy: potential impact of the CD4 cell count at initiation on clinical efficacy--results from the ANRS CO4 cohort.
- Authors
Fontas, Eric; Kousignian, Isabelle; Pradier, Christian; Poizot-Martin, Isabelle; Durier, Christine; Weiss, Laurence; Levy, Yves; Costagliola, Dominique; FHDH ANRS CO4; ANRS CO14
- Abstract
We investigated why, despite its beneficial effect on the CD4 cell count, IL-2 therapy had no clinical benefit as shown in the ESPRIT and SILCAAT trials. We focused on subgroups of patients defined according to CD4 cell counts at baseline and over time to assess the threshold above which IL-2 therapy was no longer beneficial in a large cohort of HIV-1 infected patients.
- Publication
The Journal of antimicrobial chemotherapy, 2010, Vol 65, Issue 10, p2215
- ISSN
1460-2091
- Publication type
Journal Article
- DOI
10.1093/jac/dkq296