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Title
Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort.
Authors
Carr, Daniel F; la Porte, Charles J L; Pirmohamed, Munir; Owen, Andrew; Cortes, Claudia P
Abstract
Efavirenz is extensively metabolized by CYP2B6, and associations between CYP2B6 polymorphisms and plasma efavirenz exposure have been reported. The objective of this study was to investigate CYP2B6 haplotype structure and functional consequences in a Latin American population.
Publication
The Journal of antimicrobial chemotherapy, 2010, Vol 65, Issue 9, p1889