We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic analysis of extensively drug-resistant Mycobacterium tuberculosis strains in Lisbon, Portugal.
- Authors
Perdigão, João; Macedo, Rita; Malaquias, Ana; Ferreira, Ana; Brum, Laura; Portugal, Isabel
- Abstract
Extensively drug-resistant (XDR) tuberculosis (TB) threatens the global control of TB worldwide. Lisbon has a high XDR-TB rate [50% of the multidrug-resistant tuberculosis (MDR-TB)], which is mainly associated with Lisboa family strains. Few studies have addressed the identification of mutations associated with resistance to second-line injectable drugs, and the relative frequency of such mutations varies geographically. The aim of this study was to characterize the genetic changes associated with the high number of XDR-TB cases in Lisbon.
- Publication
The Journal of antimicrobial chemotherapy, 2010, Vol 65, Issue 2, p224
- ISSN
1460-2091
- Publication type
Journal Article
- DOI
10.1093/jac/dkp452