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- Title
Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution.
- Authors
Roberts, Jason A; Kirkpatrick, Carl M J; Roberts, Michael S; Robertson, Thomas A; Dalley, Andrew J; Lipman, Jeffrey
- Abstract
To compare the plasma and subcutaneous tissue concentration-time profiles of meropenem administered by intermittent bolus dosing or continuous infusion to critically ill patients with sepsis and without renal dysfunction, and to use population pharmacokinetic modelling and Monte Carlo simulations to assess the cumulative fraction of response (CFR) against Gram-negative pathogens likely to be encountered in critical care units.
- Publication
The Journal of antimicrobial chemotherapy, 2009, Vol 64, Issue 1, p142
- ISSN
1460-2091
- Publication type
Journal Article
- DOI
10.1093/jac/dkp139