We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mutations associated with virological response to darunavir/ritonavir in HIV-1-infected protease inhibitor-experienced patients.
- Authors
Diane Descamps; Sidonie Lambert-Niclot; Anne-Geneviève Marcelin; Gilles Peytavin; Bénédicte Roquebert; Christine Katlama; Patrick Yeni; Mathieu Felices; Vincent Calvez; Françoise Brun-Vézinet
- Abstract
Objective The aim of the study was to identify a pattern of protease gene mutations associated with the virological response to darunavir/ritonavir-based regimens. Patients and methods We analysed 153 treatment-experienced patients receiving a darunavir/ritonavir salvage regimen as a sole protease inhibitor (PI). Virological response was defined as an HIV-1 RNA load of Results The baseline median HIV RNA level was 4.7 log10 copies/mL and the median CD4 cell count was 142 cells/mm3. At month 3, 55% of patients had a virological response and the median fall in viral load from baseline was 1.7 log10 copies/mL. All the patients had detectable darunavir concentrations at month 3. Cochran–Armitage procedure identified eight mutations with a negative impact on the virological response, namely K14R, K20I, E34Q, I47V, I54M, K55R, T74P and I84V; and two mutations (E35D and V82A) with a positive impact. In multivariate analyses, our genotypic scores were highly predictive of the virological response at month 3, along with the baseline plasma viral load and enfuvirtide co-prescription to enfuvirtide-naive patients. Conclusions Among the eight mutations with a negative impact on the virological response, I47V, I54M, T74P and I84V were previously described as darunavir resistance-associated mutations. Some PI resistance mutations had a positive impact on the virological response. These findings might help to explain the potency of darunavir/ritonavir on PI-resistant HIV.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2009, Vol 63, Issue 3, p585
- ISSN
0305-7453
- Publication type
Academic Journal
- DOI
10.1093/jac/dkn544