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- Title
Pre- and post-exposure prophylaxis of experimental Burkholderia pseudomallei infection with doxycycline, amoxicillin/clavulanic acid and co-trimoxazole.
- Authors
Sivalingam, Suppiah Paramalingam; Sim, Siew Hoon; Jasper, Liaw Chin Wen; Wang, Dongling; Liu, Yichun; Ooi, Eng Eong
- Abstract
Melioidosis, a potentially fatal disease of humans and animals, is caused by the gram-negative bacterium, Burkholderia pseudomallei. There is no approved vaccine or effective prophylaxis. Given its potential as a bioterrorism agent and a cause of serious laboratory-acquired infection, we studied the efficacy of pre- and post-exposure oral antibiotic prophylaxis in BALB/c mice infected with aerosolized B. pseudomallei through the inhalational route.
- Publication
The Journal of antimicrobial chemotherapy, 2008, Vol 61, Issue 3, p674
- ISSN
1460-2091
- Publication type
Journal Article
- DOI
10.1093/jac/dkm527