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- Title
Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli.
- Authors
Tilley, Lucas D; Mellbye, Brett L; Puckett, Susan E; Iversen, Patrick L; Geller, Bruce L
- Abstract
Phosphorodiamidate morpholino oligomers (PMOs) are DNA analogues that inhibit translation by an antisense mechanism. Membrane-penetrating peptides attached to PMOs increase PMO efficacy by enhancing penetration through bacterial membranes. The objectives of these experiments are to demonstrate gene-specific efficacy and establish a dose-response relationship of a peptide-PMO conjugate.
- Publication
The Journal of antimicrobial chemotherapy, 2007, Vol 59, Issue 1, p66
- ISSN
0305-7453
- Publication type
Journal Article
- DOI
10.1093/jac/dkl444