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- Title
Trends of penicillin and erythromycin resistance among invasive Streptococcus pneumoniae in Europe.
- Authors
Nienke Bruinsma; Karl G. Kristinsson; Stef Bronzwaer; Paul Schrijnemakers; John Degener; Edine Tiemersma; Waleria Hryniewicz; Jos Monen; Hajo Grundmann
- Abstract
Objectives: To forecast trends in resistance to penicillin and erythromycin among Streptococcus pneumoniae in Europe.Methods: Since 1999, the European Antimicrobial Resistance Surveillance System (EARSS) has collected routine antimicrobial susceptibility test results of S. pneumoniae. To observe and predict changes of reduced susceptibility over time, we used a multinomial logistic regression model.Results: Large variations in penicillin and erythromycin non-susceptibility were observed between countries, and reduced susceptibility to erythromycin (17%) has become more frequent than reduced susceptibility to penicillin (10%) in Europe overall. An overall decrease in single penicillin non-susceptibility, but an increase in dual non-susceptibility was observed, indicating a shift of single penicillin to combined non-susceptibility with erythromycin. By 2006, the proportion of single erythromycin and dual non-susceptibility could increase to as much as 20.4% and 8.9%, respectively.Conclusions: Our results indicate that appropriately dosed -lactams for empirical therapy are still the treatment of choice, and that macrolides should be used with prudence.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2004, Vol 54, Issue 6, p1045
- ISSN
0305-7453
- Publication type
Academic Journal
- DOI
10.1093/jac/dkh458