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- Title
Relationships among various nucleoside resistance-conferring mutations in the reverse transcriptase of HIV-1.
- Authors
Turner, Dan; Brenner, Bluma; Wainberg, Mark A
- Abstract
Highly active antiretroviral therapy has significantly improved HIV-related morbidity and mortality, and nucleoside reverse transcriptase inhibitors remain an essential component of treatment. However, the emergence of HIV-1 mutated strains that are resistant to one or more antiretroviral drugs is a leading cause of treatment failure among patients living with HIV/AIDS. These resistant strains may often suffer from a replication disadvantage in comparison with wild-type viruses when grown in the absence of drug pressure and a potential benefit in this regard has been shown for lamivudine-resistant viruses that contain a M184V mutation in reverse transcriptase, as well as for several other drug-resistant viral variants. Interactions between different mutations may complicate the understanding of HIV drug resistance with regard to the likelihood of therapeutic success.
- Publication
The Journal of antimicrobial chemotherapy, 2004, Vol 53, Issue 1, p53
- ISSN
0305-7453
- Publication type
Journal Article
- DOI
10.1093/jac/dkh009