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- Title
Mastic gum has no effect on Helicobacter pylori load in vivo.
- Authors
J.R. Bebb; N. Bailey-Flitter; D. Ala'Aldeen; J.C. Atherton
- Abstract
Objective: To determine whether mastic gum suppresses or eradicates Helicobacter pylori infection in humans. Patients and methods: Nine patients with H. pylori infection, and without gastroduodenal ulceration, were recruited from day-case endoscopy lists and treated with mastic 1 g four times daily for 14 days. [13C]Urea breath tests (UBTs) were carried out immediately before, on day 15 and 5 weeks after treatment with mastic. Results: Mastic had no effect on H. pylori status in any of the eight completed patients; all remained H. pylori positive by UBT with no change in δ scores [pre-treatment mean ± s.e.m. 19.1 ± 3.7, day 15 (post-treatment) 18.7 ± 3.8, P = 0.8, paired t-test]. Conclusion: Despite reported anti-H. pylori action in vitro, this preliminary study shows that mastic has no effect on H. pylori in humans.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2003, Vol 52, Issue 3, p522
- ISSN
0305-7453
- Publication type
Academic Journal
- DOI
10.1093/jac/dkg366