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- Title
Continuous infusion ceftazidime in intensive care: a randomized controlled trial.
- Authors
Lipman, J; Gomersall, C D; Gin, T; Joynt, G M; Young, R J
- Abstract
We randomized 18 critically ill patients to receive ceftazidime 6 g/day by continuous infusion or bolus dosing (2 g 8 hourly), each with a loading dose of 12 mg/kg ceftazidime. During the first 8 h, plasma ceftazidime concentration fell below 40 mg/L in only one patient (trough 38 mg/L) from the infusion group, compared with eight from the bolus group (2-33 mg/L) for periods ranging from 73 to 369 min. Thereafter all infusion patients remained above 40 mg/L for 40 h of study versus 20-30% of bolus patients. The pharmacokinetic and pharmacodynamic characteristics of ceftazidime suggest that continuous infusions should be clinically investigated in outcome studies.
- Publication
The Journal of antimicrobial chemotherapy, 1999, Vol 43, Issue 2, p309
- ISSN
0305-7453
- Publication type
Journal Article
- DOI
10.1093/jac/43.2.309