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- Title
The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function.
- Authors
Yumi Sawatani; Takeshi Miyamoto; Shigenori Nagai; Mikako Maruya; Jun Imai; Kana Miyamoto; Nobuyuki Fujita; Ken Ninomiya; Toru Suzuki; Ryotaro Iwasaki; Yoshiaki Toyama; Masanori Shinohara; Shigeo Koyasu; Toshio Suda
- Abstract
Regulation of dendritic cell (DC) function is critical for maintaining self-tolerance and preventing autoimmunity. The dendritic cell-specific transmembrane protein (DC-STAMP) plays a key role in cell–cell fusion of osteoclasts and foreign body giant cells, but though originally identified in DCs, its specific roles there remain undefined. Here, we report that aged DC-STAMP-deficient mice display several systemic autoimmune symptoms such as spontaneous lymphoproliferation, splenomegaly associated with infiltration of T cells in several organs and increased serum anti-double-stranded DNA antibody production. Although a lack of DC-STAMP did not inhibit DC differentiation or proliferation, antigen presentation activity of DC-STAMP-deficient DCs was significantly up-regulated in both class I and II pathways through increased phagocytotic activity compared with wild-type DCs, an activity likely leading to autoimmunity. Our results indicate that DC-STAMP is required for proper regulation of DC activity and maintenance of immune self-tolerance.
- Publication
International Immunology, 2008, Vol 20, Issue 10, p1259
- ISSN
0953-8178
- Publication type
Academic Journal
- DOI
10.1093/intimm/dxn082