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- Title
CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine.
- Authors
Nayak, Jennifer L; Fitzgerald, Theresa F; Richards, Katherine A; Yang, Hongmei; Treanor, John J; Sant, Andrea J
- Abstract
The ability of influenza vaccines to elicit CD4(+) T cells and the relationship between induction of CD4(+) T cells and vaccine-induced neutralizing antibody responses has been controversial. The emergence of swine-origin 2009 pandemic influenza A virus subtype H1N1 (A[H1N1]pdm09) provided a unique opportunity to examine responses to an influenza vaccine composed of both novel and previously encountered antigens and to probe the relationship between B-cell and T-cell responses to vaccination.
- Publication
The Journal of infectious diseases, 2013, Vol 207, Issue 2, p297
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1093/infdis/jis684