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- Title
Effects of short-course zidovudine on the selection of nevirapine-resistant HIV-1 in women taking single-dose nevirapine.
- Authors
Micek, Mark A; Blanco, Ana Judith; Carlsson, Jacquelyn; Beck, Ingrid A; Dross, Sandra; Matunha, Laurinda; Seidel, Kristy; Montoya, Pablo; Gantt, Soren; Matediana, Eduardo; Jamisse, Lilia; Gloyd, Stephen; Frenkel, Lisa M
- Abstract
Single-dose nevirapine (sdNVP) given to prevent mother-to-child-transmission of HIV-1 selects NVP-resistance. Short-course zidovudine (ZDV) was hypothesized to lower rates of NVP-resistance. HIV-1 infected pregnant women administered sdNVP with or without short-course ZDV were assessed for HIV-1 mutations (K103N, Y181C, G190A, and V106M) prior to delivery and postpartum. Postpartum NVP-resistance was lower among 31 taking ZDV+sdNVP compared to 33 taking only sdNVP (35.5% vs. 72.7%; χ2 P = .003). NVP mutants decayed to <2% in 24/35 (68.6%) at a median 6 months postpartum, with no differences based on ZDV use (logrank P = .99). Short-course ZDV was associated with reduced NVP-resistance mutations among women taking sdNVP.
- Publication
The Journal of infectious diseases, 2012, Vol 205, Issue 12, p1811
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1093/infdis/jis282