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- Title
Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection.
- Authors
Skurnik, David; Davis, Michael R, Jr; Benedetti, Dennis; Moravec, Katie L; Cywes-Bentley, Colette; Roux, Damien; Traficante, David C; Walsh, Rebecca L; Maira-Litràn, Tomas; Cassidy, Sara K; Hermos, Christina R; Martin, Thomas R; Thakkallapalli, Erin L; Vargas, Sara O; McAdam, Alexander J; Lieberman, Tami D; Kishony, Roy; Lipuma, John J; Pier, Gerald B; Goldberg, Joanna B; Priebe, Gregory P
- Abstract
New therapeutic targets for antibiotic-resistant bacterial pathogens are desperately needed. The bacterial surface polysaccharide poly-β-(1-6)-N-acetyl-glucosamine (PNAG) mediates biofilm formation by some bacterial species, and antibodies to PNAG can confer protective immunity. By analyzing sequenced genomes, we found that potentially multidrug-resistant bacterial species such as Klebsiella pneumoniae, Enterobacter cloacae, Stenotrophomonas maltophilia, and the Burkholderia cepacia complex (BCC) may be able to produce PNAG. Among patients with cystic fibrosis patients, highly antibiotic-resistant bacteria in the BCC have emerged as problematic pathogens, providing an impetus to study the potential of PNAG to be targeted for immunotherapy against pan-resistant bacterial pathogens.
- Publication
The Journal of infectious diseases, 2012, Vol 205, Issue 11, p1709
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1093/infdis/jis254