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- Title
Immunologic basis of cardiovascular disease in HIV-infected adults.
- Authors
Hsue, Priscilla Y; Deeks, Steven G; Hunt, Peter W
- Abstract
Cardiovascular complications are more common in human immunodeficiency virus-infected individuals than in age-matched uninfected individuals. Antiretroviral therapy reduces the risk of cardiovascular complications, suggesting that viral replication directly or indirectly causes vascular disease. Long-term effective antiretroviral therapy does not fully restore vascular health, and treated adults continue to have higher-than-expected rates of disease progression. Although this excess risk during therapy is likely due to multiple factors, a growing body of evidence suggests that chronic inflammation, which persists during effective antiretroviral therapy, is directly and causally associated with vascular dysfunction and the accelerated development of atherosclerosis.
- Publication
The Journal of infectious diseases, 2012, Vol 205 Suppl 3, pS375
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1093/infdis/jis200