We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Male circumcision and herpes simplex virus type 2 infection in female partners: a randomized trial in Rakai, Uganda.
- Authors
Tobian, Aaron A R; Kigozi, Godfrey; Redd, Andrew D; Serwadda, David; Kong, Xiangrong; Oliver, Amy; Nalugoda, Fred; Quinn, Thomas C; Gray, Ronald H; Wawer, Maria J
- Abstract
Male circumcision reduces acquisition of herpes simplex virus type 2 (HSV-2) in men. We assessed whether male circumcision reduces HSV-2 infection among female partners. HSV-2-negative, human immunodeficiency virus-negative female partners of 368 males who were and 372 males who were not randomized to receive male circumcision were enrolled. The incidence of HSV-2 infection among females over a period of 2 years was 6.09 cases per 100 person-years in the intervention arm and 6.32 cases per 100 person-years in the control arm (incidence rate ratio [IRR], 0.96 [95% confidence interval {CI}, .62-1.49]; P = .87). Among female partners of HSV-2-positive males, the incidence of HSV-2 infection was 9.55 cases per 100 person-years in the intervention arm and 11.17 cases per 100 person-years in the control arm (IRR, 0.85 [95% CI, .44-1.67]; P = .62). Contrary to findings in males, male circumcision did not affect HSV-2 acquisition among female partners.
- Publication
The Journal of infectious diseases, 2012, Vol 205, Issue 3, p486
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1093/infdis/jir767