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- Title
Raltegravir treatment intensification does not alter cerebrospinal fluid HIV-1 infection or immunoactivation in subjects on suppressive therapy.
- Authors
Dahl, Viktor; Lee, Evelyn; Peterson, Julia; Spudich, Serena S; Leppla, Idris; Sinclair, Elizabeth; Fuchs, Dietmar; Palmer, Sarah; Price, Richard W
- Abstract
Despite suppression of plasma human immunodeficiency virus type 1 (HIV-1) RNA by antiretroviral therapy to levels below clinical assay detection, infection and immune activation may persist within the central nervous system and possibly lead to continued brain injury. We hypothesized that intensifying therapy would decrease cerebrospinal fluid (CSF) infection and immune activation.
- Publication
The Journal of infectious diseases, 2011, Vol 204, Issue 12, p1936
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1093/infdis/jir667