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- Title
Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children.
- Authors
Hoft, Daniel F; Babusis, Elizabeth; Worku, Shewangizaw; Spencer, Charles T; Lottenbach, Kathleen; Truscott, Steven M; Abate, Getahun; Sakala, Isaac G; Edwards, Kathryn M; Creech, C Buddy; Gerber, Michael A; Bernstein, David I; Newman, Frances; Graham, Irene; Anderson, Edwin L; Belshe, Robert B
- Abstract
Two doses of either trivalent live attenuated or inactivated influenza vaccines (LAIV and TIV, respectively) are approved for young children (≥ 24 months old for LAIV and ≥ 6 months old for TIV) and induce protective antibody responses. However, whether combinations of LAIV and TIV are safe and equally immunogenic is unknown. Furthermore, LAIV is more protective than TIV in children for unclear reasons.
- Publication
The Journal of infectious diseases, 2011, Vol 204, Issue 6, p845
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1093/infdis/jir436