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- Title
Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase.
- Authors
Peng, Lee F; Schaefer, Esperance A K; Maloof, Nicole; Skaff, Andrew; Berical, Andrew; Belon, Craig A; Heck, Julie A; Lin, Wenyu; Frick, David N; Allen, Todd M; Miziorko, Henry M; Schreiber, Stuart L; Chung, Raymond T
- Abstract
Hepatitis C virus (HCV) chronically infects >170 million persons worldwide and is a leading cause of cirrhosis and hepatocellular carcinoma. The identification of more effective and better-tolerated agents for treating HCV is a high priority. We have reported elsewhere the discovery of the anti-HCV compound ceestatin using a high-throughput screen of a small molecule library.
- Publication
The Journal of infectious diseases, 2011, Vol 204, Issue 4, p609
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1093/infdis/jir303