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- Title
Varicella zoster virus DNA at inoculation sites and in saliva after Zostavax immunization.
- Authors
Pierson, Duane L; Mehta, Satish K; Gilden, Don; Cohrs, Randall J; Nagel, Maria A; Schmid, D Scott; Tyring, Stephen K
- Abstract
Analysis of 36 individuals over age 60 years who were immunized with Zostavax revealed varicella zoster virus (VZV) DNA in swabs of skin inoculation sites obtained immediately after immunization in 18 (50%) of 36 subjects (copy number per nanogram of total DNA, 28 to 2.1 × 10(6)) and in saliva collected over 28 days in 21 (58%) of 36 subjects (copy number, 20 to 248). Genotypic analysis of DNA extracted from 9 random saliva samples identified vaccine virus in all instances. In some immunized individuals over age 60, vaccine virus DNA is shed in saliva up to 4 weeks.
- Publication
The Journal of infectious diseases, 2011, Vol 203, Issue 11, p1542
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1093/infdis/jir139