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- Title
Risk of early or severe preeclampsia related to pre-existing conditions.
- Authors
Janet M Catov; Roberta B Ness; Kevin E Kip; Jorn Olsen
- Abstract
Background Preeclampsia (PE), especially severe or early PE, is a leading cause of morbidity and mortality among mothers and infants. We estimated the population attributable fractions of severe or early PE associated with pre-existing conditions among nulliparous and multiparous women. Methods Among 70 924 women in the Danish National Birth Cohort, we used hospital discharge data to identify 2117 cases of PE, of which 449 were early (Results Pre-existing hypertension, diabetes, obesity or multiple gestation were associated with 22.3% (19.8–24.9) of all PE cases among nulliparous women. These conditions, or a prior preeclamptic pregnancy, were associated with 52.2% (46.4–57.9) of PE among multiparous women. Early PE was preceded by these pre-existing conditions among 34% (28.3–40.0) of affected nulliparous women and among 50% (37.5–63.4) of multiparous women. The fraction of severe PE associated with these conditions was 23% among nulliparas and 59% among multiparas. Being obese or overweight was associated with 15–17% of the population risk of early PE among nulliparous and multiparous women. Conclusions Pre-existing maternal and obstetric conditions are associated with a high proportion of severe or early cases of PE. Obesity and overweight contributed independently to the risk of pre-term PE, a finding with potentially profound public health implications.
- Publication
International Journal of Epidemiology, 2007, Vol 36, Issue 2, p412
- ISSN
0300-5771
- Publication type
Academic Journal
- DOI
10.1093/ije/dyl271