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- Title
TGFbeta1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps.
- Authors
Sparks, Rachel; Bigler, Jeannette; Sibert, Justin G; Potter, John D; Yasui, Yutaka; Ulrich, Cornelia M
- Abstract
Transforming growth factor-beta1 (TGFbeta1) is a multifunctional signalling molecule with a wide array of roles. Animal experiments suggest that TGFbeta1 plays a biphasic role in carcinogenesis by protecting against the early formation of benign epithelial growths, but promoting malignant transformation of those growths that do develop. A polymorphism in the signal peptide sequence of the TGFbeta1 gene (L10P) has been associated with increased levels of plasma TGFbeta1 in individuals with the P allele.
- Publication
International journal of epidemiology, 2004, Vol 33, Issue 5, p955
- ISSN
0300-5771
- Publication type
Journal Article
- DOI
10.1093/ije/dyh102