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- Title
Oocyte activation, phospholipase C zeta and human infertility.
- Authors
Kashir, J; Heindryckx, B; Jones, C; De Sutter, P; Parrington, J; Coward, K
- Abstract
Mammalian oocytes are activated by intracellular calcium (Ca(2+)) oscillations following gamete fusion. Recent evidence implicates a sperm-specific phospholipase C zeta, PLCζ, which is introduced into the oocyte following membrane fusion, as the responsible factor. This review summarizes the current understanding of human oocyte activation failure and describes recent discoveries linking certain cases of male infertility with defects in PLCζ expression and activity. How these latest findings may influence future diagnosis and treatment options are also discussed.
- Publication
Human reproduction update, 2010, Vol 16, Issue 6, p690
- ISSN
1460-2369
- Publication type
Journal Article
- DOI
10.1093/humupd/dmq018