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- Title
Fertile offspring derived from mouse spermatogonial stem cells cryopreserved for more than 14 years.
- Authors
Wu, Xin; Goodyear, Shaun M; Abramowitz, Lara K; Bartolomei, Marisa S; Tobias, John W; Avarbock, Mary R; Brinster, Ralph L
- Abstract
Approximately 80% of childhood cancers can now be cured but a side effect of treatment results in about one-third of the surviving boys being infertile or severely subfertile when they reach reproductive age. Currently, more than 1 in 5000 men of reproductive age who are childhood cancer survivors suffer from this serious quality of life problem. It is possible to obtain a testicular biopsy before treatment to preserve the spermatogonial stem cells (SSCs) of the male by cryopreservation, but the results of long-term storage of SSCs on their subsequent functional ability to generate normal offspring has not been examined in any mammalian species. Moreover, it will be necessary to increase the number of these cryopreserved SSCs to remove any contaminating malignant cells and assure regeneration of spermatogenesis.
- Publication
Human reproduction (Oxford, England), 2012, Vol 27, Issue 5, p1249
- ISSN
1460-2350
- Publication type
Journal Article
- DOI
10.1093/humrep/des077