We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evidence of subpopulations with different levels of insulin resistance in women with polycystic ovary syndrome.
- Authors
Pilar Vigil; Patricio Contreras; Jorge L. Alvarado; Ana Godoy; Ana M. Salgado; Manuel E. Cortés
- Abstract
BACKGROUND Polycystic ovary syndrome (PCOS) is non-uniformly associated with insulin resistance (IR). We examined IR in women with PCOS. METHODS Sixty-nine PCOS women were subjected to the insulin suppression test (IST) to determine their steady-state plasma glucose (SSPG) as a direct measure of insulin sensitivity. RESULTS SSPG exhibited a multimodal distribution suggesting the existence of subpopulations. The heterogeneous distribution of plasma glucose at 180 min (P = 0.011), with three modes, suggested differences in the plasma glucose level trajectories during the IST. Hence, the population was separated into three groups: (i) (n = 33), subjects with SSPG ⤠152.5 mg/dl, corresponding to the first to fifth deciles; (ii) (n = 29), subjects in the interval 152.5 mg/dl n = 7), subjects with SSPG > 300 mg/dl, corresponding to the tenth decile. Plasma glucose distributions at 180 min showed differences in their mean values and ranges among groups (P P CONCLUSIONS insulin sensitivity in our patients exhibited a discontinuous distribution, implying that PCOS is a heterogeneous disorder possessing subpopulations regarding IR.
- Publication
Human Reproduction, 2007, Vol 22, Issue 11, p2974
- ISSN
0268-1161
- Publication type
Academic Journal
- DOI
10.1093/humrep/dem302