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- Title
Origins of vaginal acidity: high D/L lactate ratio is consistent with bacteria being the primary source.
- Authors
Boskey, E R; Cone, R A; Whaley, K J; Moench, T R
- Abstract
The origin of the lactic acid that acidifies the vagina is not well established. It is widely accepted that during times of high oestrogen (during the neonatal period and again during a woman's reproductive years) large amounts of glycogen are deposited in the vaginal epithelium and that the glycogen is anaerobically metabolized to lactic acid. What is not established is whether lactic acid is primarily produced by vaginal bacteria or by vaginal epithelial cells. Human cells can make only L-lactate, while bacteria can produce both D- and L-, thus the D- to L-lactate ratio can indicate the relative contribution of bacterially derived lactic acid.
- Publication
Human reproduction (Oxford, England), 2001, Vol 16, Issue 9, p1809
- ISSN
0268-1161
- Publication type
Journal Article
- DOI
10.1093/humrep/16.9.1809