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- Title
Sex- and age-interacting eQTLs in human complex diseases.
- Authors
Yao, Chen; Joehanes, Roby; Johnson, Andrew D; Huan, Tianxiao; Esko, Tõnu; Ying, Saixia; Freedman, Jane E; Murabito, Joanne; Lunetta, Kathryn L; Metspalu, Andres; Munson, Peter J; Levy, Daniel
- Abstract
Many complex human diseases exhibit sex or age differences in gene expression. However, the presence and the extent of genotype-specific variations in gene regulation are largely unknown. Here, we report results of a comprehensive analysis of expression regulation of genetic variation related to 11,672 complex disease-associated SNPs as a function of sex and age in whole-blood-derived RNA from 5254 individuals. At false discovery rate <0.05, we identified 14 sex- and 10 age-interacting expression quantitative trait loci (eQTLs). We show that these eQTLs are also associated with many sex- or age-associated traits. These findings provide important context regarding the regulation of phenotypes by genotype-environment interaction.
- Publication
Human molecular genetics, 2014, Vol 23, Issue 7, p1947
- ISSN
1460-2083
- Publication type
Journal Article
- DOI
10.1093/hmg/ddt582