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- Title
Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes.
- Authors
Qi, Lu; Cornelis, Marilyn C; Kraft, Peter; Jensen, Majken; van Dam, Rob M; Sun, Qi; Girman, Cynthia J; Laurie, Cathy C; Mirel, Daniel B; Hunter, David J; Rimm, Eric; Hu, Frank B
- Abstract
Blood soluble E-selectin (sE-selectin) levels have been related to various conditions such as type 2 diabetes. We performed a genome-wide association study among women of European ancestry from the Nurses' Health Study, and identified genome-wide significant associations between a cluster of markers at the ABO locus (9q34) and plasma sE-selectin concentration. The strongest association was with rs651007, which explained approximately 9.71% of the variation in sE-selectin concentrations. SNP rs651007 was also nominally associated with soluble intracellular cell adhesion molecule-1 (sICAM-1) (P = 0.026) and TNF-R2 levels (P = 0.018), independent of sE-selectin. In addition, the genetic-inferred ABO blood group genotypes were associated with sE-selectin concentrations (P = 3.55 x 10(-47)). Moreover, we found that the genetic-inferred blood group B was associated with a decreased risk (OR = 0.44, 0.27-0.70) of type 2 diabetes compared with blood group O, adjusting for sE-selectin, sICAM-1, TNF-R2 and other covariates. Our findings indicate that the genetic variants at ABO locus affect plasma sE-selectin levels and diabetes risk. The genetic associations with diabetes risk were independent of sE-selectin levels.
- Publication
Human molecular genetics, 2010, Vol 19, Issue 9, p1856
- ISSN
1460-2083
- Publication type
Journal Article
- DOI
10.1093/hmg/ddq057