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Title
Molecular basis of pluripotency.
Authors
Chen, Lingyi; Daley, George Q
Abstract
Embryonic stem (ES) cells are pluripotent and capable of self-renewal, thus holding promise for regenerative medicine. Recent studies have begun to provide insights into the molecular mechanisms underlying pluripotency and self-renewal. In this article, we discuss the roles of transcriptional regulation, epigenetic regulation and miRNAs in the maintenance of pluripotency and the differentiation of ES cells.
Publication
Human molecular genetics, 2008, Vol 17, Issue R1, pR23