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- Title
Genetic variation in DTNBP1 influences general cognitive ability.
- Authors
Burdick, Katherine E; Lencz, Todd; Funke, Birgit; Finn, Christine T; Szeszko, Philip R; Kane, John M; Kucherlapati, Raju; Malhotra, Anil K
- Abstract
Human intelligence is a trait that is known to be significantly influenced by genetic factors, and recent linkage data provide positional evidence to suggest that a region on chromosome 6p, previously associated with schizophrenia, may be linked to variation in intelligence. The gene for dysbindin-1 (DTNBP1) is located at 6p and has also been implicated in schizophrenia, a neuropsychiatric disorder characterized by cognitive dysfunction. We report an association between DTNBP1 genotype and general cognitive ability (g) in two independent cohorts, including 213 patients with schizophrenia or schizo-affective disorder and 126 healthy volunteers. These data suggest that DTNBP1 genetic variation influences human intelligence.
- Publication
Human molecular genetics, 2006, Vol 15, Issue 10, p1563
- ISSN
0964-6906
- Publication type
Journal Article
- DOI
10.1093/hmg/ddi481