We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A gene for non-syndromic autosomal dominant progressive postlingual sensorineural hearing loss maps to chromosome 14q12-13.
- Authors
Manolis, E N; Yandavi, N; Nadol, J B, Jr; Eavey, R D; McKenna, M; Rosenbaum, S; Khetarpal, U; Halpin, C; Merchant, S N; Duyk, G M; MacRae, C; Seidman, C E; Seidman, J G
- Abstract
We report a novel locus responsible for postlingual progressive sensorineural hearing loss (designated DFNA9) that maps to chromosome 14q12-13. A large kindred with autosomal dominant transmission of non-syndromic hearing loss was clinically studied. Hearing in affected individuals deteriorated at approximately 20 years of age and progressed to anacusis in the fifth decade. A random genome-wide search using polymorphic short tandem repeats demonstrated linkage with D14S121 (maximum two point LOD score = 6.19, theta = 0). Haplotype analysis of recombination events defined a 9 cM disease interval, between D14S252 and D14S49.
- Publication
Human molecular genetics, 1996, Vol 5, Issue 7, p1047
- ISSN
0964-6906
- Publication type
Journal Article
- DOI
10.1093/hmg/5.7.1047