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- Title
Exploring biologically relevant pathways in frailty.
- Authors
Ho, Yen-Yi; Matteini, Amy M; Beamer, Brock; Fried, Linda; Xue, Qian-li; Arking, Dan E; Chakravarti, Aravinda; Fallin, M Daniele; Walston, Jeremy
- Abstract
Frailty is a late-life syndrome of vulnerability to adverse health outcomes characterized by a phenotype that includes muscle weakness, fatigue, and inflammatory pathway activation. The identification of biologically relevant pathways that influence frailty is challenged by its biological complexity and the necessity in separating disease states from the syndrome of frailty. As with longevity research, genetic analyses may help to provide insights into biologically relevant pathways that contribute to frailty.
- Publication
The journals of gerontology. Series A, Biological sciences and medical sciences, 2011, Vol 66, Issue 9, p975
- ISSN
1758-535X
- Publication type
Journal Article
- DOI
10.1093/gerona/glr061