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- Title
Is telomere length a biomarker of aging? A review.
- Authors
Mather, Karen Anne; Jorm, Anthony Francis; Parslow, Ruth Adeline; Christensen, Helen
- Abstract
Telomeres, the DNA-protein structures located at the ends of chromosomes, have been proposed to act as a biomarker of aging. In this review, the human evidence that telomere length is a biomarker of aging is evaluated. Although telomere length is implicated in cellular aging, the evidence suggesting telomere length is a biomarker of aging in humans is equivocal. More studies examining the relationships between telomere length and mortality and with measures that decline with "normal" aging in community samples are required. These studies would benefit from longitudinal measures of both telomere length and aging-related parameters.
- Publication
The journals of gerontology. Series A, Biological sciences and medical sciences, 2011, Vol 66, Issue 2, p202
- ISSN
1758-535X
- Publication type
Journal Article
- DOI
10.1093/gerona/glq180