We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy.
- Authors
Rochon, James; Bales, Connie W; Ravussin, Eric; Redman, Leanne M; Holloszy, John O; Racette, Susan B; Roberts, Susan B; Das, Sai Krupa; Romashkan, Sergei; Galan, Katherine M; Hadley, Evan C; Kraus, William E; CALERIE Study Group
- Abstract
In a robust and consistent manner, sustained caloric restriction (CR) has been shown to retard the aging process in a variety of animal species. Nonhuman primate studies suggest that CR may have similar effects in longer-lived species. The CALERIE (Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy) research program is the first systematic investigation of CR in nonobese human beings. In the phase 2 study, it is hypothesized that 2 years of sustained CR, involving a 25% reduction of ad libitum energy intake, results in beneficial effects similar to those observed in animal studies. This article presents the design and implementation of this study.
- Publication
The journals of gerontology. Series A, Biological sciences and medical sciences, 2011, Vol 66, Issue 1, p97
- ISSN
1758-535X
- Publication type
Journal Article
- DOI
10.1093/gerona/glq168