We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Accelerated features of age-related bone loss in zmpste24 metalloproteinase-deficient mice.
- Authors
Rivas, Daniel; Li, Wei; Akter, Rahima; Henderson, Janet E; Duque, Gustavo
- Abstract
Age-related bone loss is associated with changes in bone cellularity, which include marrow fat infiltration and decreasing levels of osteoblastogenesis. The mechanisms that explain these changes remain unclear. Although nuclear lamina alterations occur in premature aging syndromes that include changes in body fat and severe osteoporosis, the role of proteins of the nuclear lamina in age-related bone loss remains unknown. Using the Zmpste24-null progeroid mice (Zmpste24(-/-)), which exhibit nuclear lamina defects and accumulate unprocessed prelamin A, we identified several alterations in bone cellularity in vivo. We found that defective prelamin A processing induced accelerated features of age-related bone loss including lower osteoblast and osteocyte numbers and higher levels of marrow adipogenesis. In summary, processing of prelamin A could become a new approach to regulate osteoblastogenesis and bone turnover and thus for the prevention and treatment of senile osteoporosis.
- Publication
The journals of gerontology. Series A, Biological sciences and medical sciences, 2009, Vol 64, Issue 10, p1015
- ISSN
1758-535X
- Publication type
Journal Article
- DOI
10.1093/gerona/glp089