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- Title
Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice.
- Authors
LeBrasseur, Nathan K; Schelhorn, Teresa M; Bernardo, Barbara L; Cosgrove, Patricia G; Loria, Paula M; Brown, Thomas A
- Abstract
The objective of this study was to examine the effects of short-term exercise training, myostatin inhibition (PF-354), and exercise+PF-354, all relative to a vehicle control, on performance and metabolic measures in 24-month-old mice. At study termination, PF-354-treated mice exhibited significantly greater muscle weights. Performance measures revealed that exercise+PF-354 increased treadmill running time and distance to exhaustion (more than twofold) and increased habitual activity. Measures of strength were not different; however, all treatment groups demonstrated more than 30% reductions in muscle fatigue. Metabolic measures showed that basal metabolic rates were higher in PF-354- and exercise+PF-354-treated mice, and exercise and exercise+PF-354 groups exhibited significantly greater insulin sensitivity. PF-354 was associated with decreased Smad3 phosphorylation and increased peroxisome proliferator-activated receptor gamma coactivator-1alpha expression and, similar to exercise, decreased MuRF-1. The data suggest that the combination of exercise training and myostatin blockade may significantly improve physical function and whole-body metabolism in older individuals.
- Publication
The journals of gerontology. Series A, Biological sciences and medical sciences, 2009, Vol 64, Issue 9, p940
- ISSN
1758-535X
- Publication type
Journal Article
- DOI
10.1093/gerona/glp068