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- Title
Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging.
- Authors
Uribarri, Jaime; Cai, Weijing; Peppa, Melpomeni; Goodman, Susan; Ferrucci, Luigi; Striker, Gary; Vlassara, Helen
- Abstract
Oxidative stress (OS) and inflammatory mediators increase with aging. The levels of advanced glycation endproducts (AGEs), prooxidant factors linked to chronic diseases such as diabetes, cardiovascular disease, and renal disease, also increase with aging. AGEs are readily derived from heat-treated foods. We propose that the excess consumption of certain AGEs via the diet enhances OS and inflammatory responses in healthy adults, especially in elderly persons.
- Publication
The journals of gerontology. Series A, Biological sciences and medical sciences, 2007, Vol 62, Issue 4, p427
- ISSN
1079-5006
- Publication type
Journal Article
- DOI
10.1093/gerona/62.4.427