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- Title
The apolipoprotein E e4 polymorphism is strongly associated with poor mobility performance test results but not self-reported limitation in older people.
- Authors
Melzer, David; Dik, M G; van Kamp, Gerard J; Jonker, Cees; Deeg, Dorly J
- Abstract
The apolipoprotein E (ApoE) e4 polymorphism is linked to increased mortality rates, Alzheimer's disease, and cardiovascular disease in older people, but previous studies have largely failed to detect an effect on self-reported mobility disability. We hypothesized that poor performance on mobility-related tests may provide a better measure of effects, and we aimed to estimate the extent to which the ApoE e4 allele increases risks of poor performance on measured mobility and self-reported mobility disability compared to e3/3, in a medium-sized population cohort.
- Publication
The journals of gerontology. Series A, Biological sciences and medical sciences, 2005, Vol 60, Issue 10, p1319
- ISSN
1079-5006
- Publication type
Journal Article
- DOI
10.1093/gerona/60.10.1319