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- Title
Dual-energy x-ray absorptiometry-measured lean soft tissue mass: differing relation to body cell mass across the adult life span.
- Authors
St-Onge, Marie-Pierre; Wang, Jack; Shen, Wei; Wang, ZiMian; Allison, David B; Heshka, Stanley; Pierson, Richard N, Jr; Heymsfield, Steven B
- Abstract
Lean soft tissue (LST) measured by dual-energy X-ray absorptiometry (DEXA) is used as a metabolic measure in aging research despite evidence of extracellular fluid expansion and a corresponding reduction in body cell mass (BCM) in older participants. We investigated the hypothesis that the fraction of LST as BCM is smaller with greater age. Men and women (n = 2043) had DEXA and 40K-counting for body potassium and BCM measured on the same day. Both BCM and LST were lower with greater age but the relative lowering was larger for BCM. A multiple linear regression model was fitted with BCM/LST as the dependent variable, and age, sex, and interaction terms as independent variables. Men had a mean BCM/LST greater (p < .001) than women; quadratic and cubic age terms were also significant or approached significance. Thus, the fraction of LST as BCM is smaller in older adults, a finding that has implications for the interpretation of DEXA results.
- Publication
The journals of gerontology. Series A, Biological sciences and medical sciences, 2004, Vol 59, Issue 8, p796
- ISSN
1079-5006
- Publication type
Journal Article
- DOI
10.1093/gerona/59.8.b796