We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Isolation and characterization of high-temperature-induced Dauer formation mutants in Caenorhabditis elegans.
- Authors
Ailion, Michael; Thomas, James H
- Abstract
Dauer formation in Caenorhabditis elegans is regulated by at least three signaling pathways, including an insulin receptor-signaling pathway. These pathways were defined by mutants that form dauers constitutively (Daf-c) at 25 degrees. Screens for Daf-c mutants at 25 degrees have probably been saturated, but failed to identify all the components involved in regulating dauer formation. Here we screen for Daf-c mutants at 27 degrees, a more strongly dauer-inducing condition. Mutations identified include novel classes of alleles for three known genes and alleles defining at least seven new genes, hid-1-hid-7. Many of the genes appear to act in the insulin branch of the dauer pathway, including pdk-1, akt-1, aex-6, and hid-1. We also molecularly identify hid-1 and show that it encodes a novel highly conserved putative transmembrane protein expressed in neurons.
- Publication
Genetics, 2003, Vol 165, Issue 1, p127
- ISSN
0016-6731
- Publication type
Journal Article
- DOI
10.1093/genetics/165.1.127