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- Title
Two genes required for meiotic recombination in Drosophila are expressed from a dicistronic message.
- Authors
Liu, H; Jang, J K; Graham, J; Nycz, K; McKim, K S
- Abstract
We have isolated two alleles of a previously unidentified meiotic recombination gene, mei-217. Genetic analysis of these mutants shows that mei-217 is a typical "precondition" gene. The phenotypes of the mutants are meiosis specific. The strongest allele has <10% of the normal level of crossing over, and the residual events are distributed abnormally. We have used double mutant analysis to position mei-217 in the meiotic recombination pathway. In general, mutations causing defects in the initiation of meiotic recombination are epistatic to mutations in mei-41 and spnB. These two mutations, however, are epistatic to mei-217, suggesting that recombination is initiated normally in mei-217 mutants. It is likely that mei-217 mutants are able to make Holliday junction intermediates but are defective in the production of crossovers. These phenotypes are most similar to mutants of the mei-218 gene. This is striking because mei-217 and mei-218 are part of the same transcription unit and are most likely produced from a dicistronic message.
- Publication
Genetics, 2000, Vol 154, Issue 4, p1735
- ISSN
0016-6731
- Publication type
Journal Article
- DOI
10.1093/genetics/154.4.1735