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- Title
Synthesis of FinP RNA by plasmids F and pSLT is regulated by DNA adenine methylation.
- Authors
Torreblanca, J; Marqués, S; Casadesús, J
- Abstract
DNA adenine methylase mutants of Salmonella typhimurium contain reduced amounts of FinP, an antisense RNA encoded by the virulence plasmid pSLT. Lowered FinP levels are detected in both Dam- FinO+ and Dam- FinO- backgrounds, suggesting that Dam methylation regulates FinP production rather than FinP half-life. Reduced amounts of F-encoded FinP RNA are likewise found in Dam- mutants of Escherichia coli. A consequence of FinP RNA scarcity in the absence of DNA adenine methylation is that Dam- mutants of both S. typhimurium and E. coli show elevated levels of F plasmid transfer. Inhibition of F fertility by the S. typhimurium virulence plasmid is also impaired in a Dam- background.
- Publication
Genetics, 1999, Vol 152, Issue 1, p31
- ISSN
0016-6731
- Publication type
Journal Article
- DOI
10.1093/genetics/152.1.31