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- Title
Increased length of long terminal repeats inhibits Ty1 transposition and leads to the formation of tandem multimers.
- Authors
Lauermann, V; Hermankova, M; Boeke, J D
- Abstract
The Ty1 retrotransposon of Saccharomyces cerevisiae is bounded by long-terminal repeats (LTRs). We have constructed a variety of Ty1 elements in which the LTR length has been increased from the normal length of 334 bp to > 2 kb. Although small insertions in the LTR have minimal effects on transposition frequency, larger insertions dramatically reduce it. Nevertheless, elements with long LTRs are incorporated into the genome at a low frequency. Most of these rare insertion events represent Ty1 tandem (head to tail) multimers.
- Publication
Genetics, 1997, Vol 145, Issue 4, p911
- ISSN
0016-6731
- Publication type
Journal Article
- DOI
10.1093/genetics/145.4.911