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- Title
Destabilization of simple repetitive DNA sequences by transcription in yeast.
- Authors
Wierdl, M; Greene, C N; Datta, A; Jinks-Robertson, S; Petes, T D
- Abstract
Simple repetitive DNA sequences in the eukaryotic genome frequently alter in length. In wild-type strains, we find that transcription through a repetitive poly GT tract destabilizes the tract four- to ninefold. In mismatch repair-deficient yeast strains, simple repeats are very unstable. High levels of transcription in such strains destabilize repetitive tracts an additional two- to threefold.
- Publication
Genetics, 1996, Vol 143, Issue 2, p713
- ISSN
0016-6731
- Publication type
Journal Article
- DOI
10.1093/genetics/143.2.713