We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
LAS1 is an essential nuclear protein involved in cell morphogenesis and cell surface growth.
- Authors
Doseff, A I; Arndt, K T
- Abstract
Saccharomyces cerevisiae mutations that cause a requirement for SSD1-v for viability were isolated, yielding one new gene, LAS1, and three previously identified genes, SIT4, BCK1/SLK1, and SMP3. Three of these genes, LAS1, SIT4, and BCK1/SLK1, encode proteins that have roles in bud formation or morphogenesis. LAS1 is essential and loss of LAS1 function causes the cells to arrest as 80% unbudded cells and 20% large budded cells that accumulate many vesicles at the mother-daughter neck. Overexpression of LAS1 results in extra cell surface projections in the mother cell, alterations in actin and SPA2 localization, and the accumulation of electron-dense structures along the periphery of both the mother cell and the bud. The nuclear localization of LAS1 suggests a role of LAS1 for regulating bud formation and morphogenesis via the expression of components that function directly in these processes.
- Publication
Genetics, 1995, Vol 141, Issue 3, p857
- ISSN
0016-6731
- Publication type
Journal Article
- DOI
10.1093/genetics/141.3.857