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- Title
The relationship between CYP2C19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients: the CHARISMA genetics study.
- Authors
Bhatt, Deepak L; Paré, Guillaume; Eikelboom, John W; Simonsen, Katy L; Emison, Eileen S; Fox, Keith A A; Steg, Ph Gabriel; Montalescot, Gilles; Bhakta, Nihar; Hacke, Werner; Flather, Marcus D; Mak, Koon-Hou; Cacoub, Patrice; Creager, Mark A; Berger, Peter B; Steinhubl, Steven R; Murugesan, Gurunathan; Mehta, Shamir R; Kottke-Marchant, Kandice; Lincoff, A Michael; Topol, Eric J; CHARISMA Investigators
- Abstract
Clinical trials have established the value of clopidogrel therapy in a wide spectrum of patients with cardiovascular diseases. Both loss- and gain-of-function single nucleotide variants of CYP2C19 genes have been identified that affect clopidogrel metabolism and anti-platelet response. We sought to determine the impact of CYP2C19 polymorphisms on ischaemic and bleeding events.
- Publication
European heart journal, 2012, Vol 33, Issue 17, p2143
- ISSN
1522-9645
- Publication type
Journal Article
- DOI
10.1093/eurheartj/ehs059