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- Title
Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study.
- Authors
Gomes, John; Finlay, Malcolm; Ahmed, Akbar K; Ciaccio, Edward J; Asimaki, Angeliki; Saffitz, Jeffrey E; Quarta, Giovanni; Nobles, Muriel; Syrris, Petros; Chaubey, Sanjay; McKenna, William J; Tinker, Andrew; Lambiase, Pier D
- Abstract
Anecdotal observations suggest that sub-clinical electrophysiological manifestations of arrhythmogenic right ventricular cardiomyopathy (ARVC) develop before detectable structural changes ensue on cardiac imaging. To test this hypothesis, we investigated a murine model with conditional cardiac genetic deletion of one desmoplakin allele (DSP ±) and compared the findings to patients with non-diagnostic features of ARVC who carried mutations in desmoplakin.
- Publication
European heart journal, 2012, Vol 33, Issue 15, p1942
- ISSN
1522-9645
- Publication type
Journal Article
- DOI
10.1093/eurheartj/ehr472