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- Title
Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.
- Authors
Grallert, Harald; Dupuis, Josée; Bis, Joshua C; Dehghan, Abbas; Barbalic, Maja; Baumert, Jens; Lu, Chen; Smith, Nicholas L; Uitterlinden, André G; Roberts, Robert; Khuseyinova, Natalie; Schnabel, Renate B; Rice, Kenneth M; Rivadeneira, Fernando; Hoogeveen, Ron C; Fontes, João Daniel; Meisinger, Christa; Keaney, John F, Jr; Lemaitre, Rozenn; Aulchenko, Yurii S; Vasan, Ramachandran S; Ellis, Stephen; Hazen, Stanley L; van Duijn, Cornelia M; Nelson, Jeanenne J; März, Winfried; Schunkert, Heribert; McPherson, Ruth M; Stirnadel-Farrant, Heide A; Psaty, Bruce M; Gieger, Christian; Siscovick, David; Hofman, Albert; Illig, Thomas; Cushman, Mary; Yamamoto, Jennifer F; Rotter, Jerome I; Larson, Martin G; Stewart, Alexandre F R; Boerwinkle, Eric; Witteman, Jacqueline C M; Tracy, Russell P; Koenig, Wolfgang; Benjamin, Emelia J; Ballantyne, Christie M
- Abstract
Lipoprotein-associated phospholipase A2 (Lp-PLA2) generates proinflammatory and proatherogenic compounds in the arterial vascular wall and is a potential therapeutic target in coronary heart disease (CHD). We searched for genetic loci related to Lp-PLA2 mass or activity by a genome-wide association study as part of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.
- Publication
European heart journal, 2012, Vol 33, Issue 2, p238
- ISSN
1522-9645
- Publication type
Journal Article
- DOI
10.1093/eurheartj/ehr372