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- Title
Mesenchymal stem cells improve murine acute coxsackievirus B3-induced myocarditis.
- Authors
Van Linthout, S; Savvatis, K; Miteva, K; Peng, J; Ringe, J; Warstat, K; Schmidt-Lucke, C; Sittinger, M; Schultheiss, H-P; Tschöpe, C
- Abstract
Coxsackievirus B3 (CVB3)-induced myocarditis, initially considered a sole immune-mediated disease, also results from a direct CVB3-mediated injury of the cardiomyocytes. Mesenchymal stem cells (MSCs) have, besides immunomodulatory, also anti-apoptotic features. In view of clinical translation, we first analysed whether MSCs can be infected by CVB3. Next, we explored whether and how MSCs could reduce the direct CVB3-mediated cardiomyocyte injury and viral progeny release, in vitro, in the absence of immune cells. Finally, we investigated whether MSC application could improve murine acute CVB3-induced myocarditis.
- Publication
European heart journal, 2011, Vol 32, Issue 17, p2168
- ISSN
1522-9645
- Publication type
Journal Article
- DOI
10.1093/eurheartj/ehq467